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27 Mar 2018, 6:16 pm by Lynn L. Bergeson and Carla N. Hutton
  The report lists the following general observations: A number of in vitro methods were used in the OECD Testing Program to assess manufactured nanomaterials, however, many in vitro data reported were not generated using OECD TGs; A number of in vitro endpoints have been assessed, but a full set of in vitro assays for a specific manufactured nanomaterial is not available; The existing in vitro TGs have not been used extensively (g., skin… [read post]
17 Mar 2009, 5:56 am
Data includes chemical structure, physico-chemical values, in vitro assay data and in vivo toxicology data. [read post]
20 Feb 2024, 10:05 am by Lynn L. Bergeson
(EST) for a webinar on the use of new approach methodologies (NAM) or alternative methods to testing on vertebrate animals for chemical risk assessments. [read post]
20 Feb 2024, 10:05 am by Lynn L. Bergeson
(EST) for a webinar on the use of new approach methodologies (NAM) or alternative methods to testing on vertebrate animals for chemical risk assessments. [read post]
25 Sep 2013, 10:03 pm by Environmental Health News
When asked if his industry involvement influenced his opinion about the proposed regulations, Bas Blaauboer, editor of the Toxicology in Vitro journal, said, “This is a very stupid question. [read post]
10 May 2017, 12:26 pm by lcampbell@lawbc.com
(B&C®) continues to monitor the development, validation, and implementation of alternative in vitro and in silico test methods, high throughput screening assays, and computational models as they are integrated into global regulatory frameworks. [read post]
9 Nov 2009, 12:00 am
Yet, until recently, scientists staunchly defended the use of live animals as the “gold standard” in testing chemicals and other products. [read post]
9 Nov 2009, 12:00 am
Yet, until recently, scientists staunchly defended the use of live animals as the “gold standard” in testing chemicals and other products. [read post]
4 Mar 2020, 6:07 pm by Lynn L. Bergeson and Carla N. Hutton
”  The CIB section on nanomaterials risk assessment includes subsections on dose normalization in vitro and in vivo and correlation of in vitro and in vivo responses. [read post]
13 Apr 2018, 12:11 pm by lcampbell@lawbc.com
Environmental Protection Agency (EPA) announced the availability of a draft Science Policy document intended to reduce the use of animals in testing chemicals to evaluate whether they cause an allergic reaction, inflammation, or sensitization of the skin. [read post]
13 Jul 2009, 6:00 am
  The sole chemical up for consideration will be Bisphenol A, an industrial chemical used to make plastic resins. [read post]
25 Apr 2023, 9:00 pm by News Desk
NAMs are any non-animal based approaches that can help provide toxicological information in chemical hazard assessments. [read post]
6 Aug 2021, 9:25 am by Lynn L. Bergeson and Carla N. Hutton
It discusses nanospecific considerations relating to in vitro/in vivo toxicological studies and outlines a tiered framework for toxicological testing. [read post]
8 May 2020, 12:46 pm by Lynn L. Bergeson and Carla N. Hutton
  This could be data on dissolution, dispersion stability, or in vitro  When these data are introduced in the app, it gives the result of the final evaluation and concludes whether the set can be justified. [read post]
8 Mar 2019, 4:08 pm by Lynn L. Bergeson and Carla N. Hutton
  In vitro assays for assessing nanomaterial genotoxicity, cytotoxicity, and uptake studies. [read post]
ANDA applicants should conduct an array of testing, beginning with simple manipulations in in vitro studies (Tier 1) and later performing more aggressive mechanical and chemical manipulations. [read post]
10 Aug 2021, 1:18 pm by Rebecca Tushnet
Acrylamide is a toxic chemical first detected in food in 2002, but not newly there. [read post]
5 May 2010, 4:59 am by Mark Zamora
Image by Felipe Skroski via FlickrThe FDA 4-Star Rating System:The FDA plans to implement include a four-star rating system for UVA protection that would be based on both in vitro and in vivo tests and incorporate a measurement of photostability.Manufacturers would be required to include the four-star rating on their sunscreen labels and would face new restrictions in what they can and cannot say on labels. [read post]
26 Jul 2017, 3:21 pm by Lynn L. Bergeson and Carla N. Hutton
 These models comprised toxicokinetic, toxicodynamic, in vitro and in vivo dosimetry, and environmental fate models. [read post]