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13 Apr 2024, 3:33 pm by admin
Prelude to Litigation Phenylpropanolamine (PPA) was a widely used direct α-adrenergic agonist used as a medication to control cold symptoms and to suppress appetite for weight loss.[1] In 1972, an over-the-counter (OTC) Advisory Review Panel considered the safety and efficacy of PPA-containing nasal decongestant medications, leading, in 1976, to a recommendation that the agency label these medications as “generally recognized as safe and effective. [read post]
23 Dec 2023, 7:16 pm by admin
Judge Weinstein observed that when the hand waving stopped, “[t]here is no evidence that plaintiffs were exposed to the far higher concentrations involved in both animal and industrial exposure studies. [read post]
25 Aug 2023, 6:22 pm by admin
As with any methodology, the Bradford Hill factors are not self-executing. [read post]
7 Apr 2023, 1:18 pm by Rebecca Tushnet
The Global Internet and Its Workable, Bespoke, Patchwork Regulation      Justin Hughes, Loyola University Los Angeles John Perry Barlow’s Declaration of Independence of Cyberspace: a full repudiation of the lack of gov’t authority or moral right to rule cyberspace. [read post]
10 Feb 2023, 4:44 am by admin
Putting aside the idiosyncratic chapter by the late Professor Berger, most of the third edition of the Reference Manual presented guidance on many important issues. [read post]
28 Jun 2022, 7:13 am by admin
The Bradford Hill Predicate: Ruling Out Random and Systematic Error In two recent posts, I spent some time discussing a recent law review, which had some important things to say about specific causation.[1] One of several points from which I dissented was the article’s argument that Sir Austin Bradford Hill had not made explicit that ruling out random and systematic error was required before assessing his nine “viewpoints” on whether an association was causal. [read post]
One future General Counsel and Chairman of the Commission wrote then that the SEC “should impose affirmative environmental disclosure requirements upon all corporate entities subject to its jurisdiction”; “[t]hat the Commission’s authority is not so limited as to preclude such an approach,” he thought, “is apparent from a reading of its statutory authority. [read post]
24 Feb 2022, 4:01 am by Administrator
Periodically on Thursdays, we present a significant excerpt, usually from a recently published book or journal article. [read post]
12 Dec 2021, 2:22 pm by admin
”[1] In other words, before we even embark on consideration of Bradford Hill’s nine considerations, we should have ruled out chance, bias, and confounding as an explanation for the claimed association.[2] Although confounding is sometimes considered as a type of systematic bias, its importance warrants its own category. [read post]
16 Oct 2021, 9:21 am by admin
In a footnote, the authors emphasized that their factual analysis and argument contradicted the industry’s desired defense.[15] Reaching back even farther in time, there is the redoubtable Irving John Selikoff, who wrote in 1991: “We are inevitably bound by the knowledge of the time in which we live. [read post]
The panelists include Barbara Cosgrove, vice president at Workday; Sharon Bradford Franklin, co-director of the Center for Democracy & Technology; Cameron Kerry, Brookings visiting fellow; and Peter Swire, professor at Georgia Tech. [read post]
16 Jul 2021, 12:30 pm by John Ross
(The events were the subject of a John Grisham book and subsequent Netflix documentary.) [read post]